Title: Phase 2 trial of sotorasib in combination with carboplatin-pemetrexed and bevacizumab-biosimilar as first line treatment for advanced non-squamous non-small cell lung cancer with KRAS G12C mutation.

The aim of the SHERLOCK trial is to assess the activity and tolerability of sotorasib in combination with carboplatin-pemetrexed and bevacizumab-biosimilar in non-squamous metastatic NSCLC with KRAS G12C mutation.  

Eligible Population: 

KRAS G12C positive newly diagnosed, treatment naïve metastatic (Stage IV) non-squamous NSCLC or recurrent non-squamous NSCLC with no disease progression for at least 6 months following prior curative lung surgery and (neo)adjuvant chemotherapy, or prior curative concurrent chemoradiotherapy and immunotherapy maintenance, for non-resectable stage III cancer.

Substudy status: Recruiting

Registration number: ACTRN12622000973718

Title: A phase II, open-label, single-arm monotherapy trial of sulfasalazine in patients with pancreatic ductal adenocarcinoma

The aim of this MoST companion study is to assess the clinical activity of sulfasalazine in MoST patients with pancreatic ductal adenocarcinoma.

Eligible Population: 

Patients with advanced pancreatic ductal adenocarcinoma and presence of tumour and/or stromal SLC7A11 expression who have progressive disease following prior treatment.

Substudy status: Recruiting

Registration number: ACTRN12621001347853

Title: A Single Arm, Open-label, Phase II Signal-seeking Trial of Tiragolumab and Atezolizumab in Patients With Advanced Solid Tumours

The aim of this study is to evaluate the effect of 2 monoclonal antibodies, tiragolumab and atezolizumab, in patients with locally advanced solid cancers which cannot be removed by surgery or have spread.

Eligible Population: 

• Histologically or cytologically confirmed locally advanced unresectable or metastatic solid tumour. Non-small cell lung cancer is excluded
• Exhausted all available standard therapy or not suitable for standard therapy (including targeted therapies) for the tumour
• Sufficient and accessible tumour tissue for panel sequencing, PD-L1 and TIL testing, and tertiary objectives
• Tumour biomarker criteria predictive of immune response defined by presence of one or more of the following: 
  • Tumour Mutation Murden ≥ 10 mutations per megabase
  • Tumour and immune cell PD-L1 expression (TAP score) > 20% high or PD-L1 (CD274) amplification >6 copy number alterations
  • Tumour and immune cell PD-L1 expression (TAP score) 5-20%
  • Tumour Infiltrating Lymphocytes (TILs) (CD3+CD8+) ≥ 5%
• Prior use of approved or investigational anti-TIGIT therapy is not eligible.
• Prior treatment with CD137 agonists or immune checkpoint blockade therapies, including anti-CTLA-4, anti-PD-1, and anti-PD-L1 therapeutic antibodies is not eligible.

Substudy status: Recruiting

Registration number: NCT06003621